Calcium-dependent cytosolic phospholipase A2 activation is implicated in neuroinflammation and oxidative stress associated with ApoE4.
Shaowei WangBoyang LiVictoria SolomonAlfred FontehStanley I RapoportDavid A BennettZoe ArvanitakisHelena C ChuiCarol MillerPatrick M SullivanHoau-Yan WangHussein N YassinePublished in: Molecular neurodegeneration (2021)
Our findings implicate greater activation of cPLA2 signaling system with APOE4, which could represent a potential drug target for mitigating the increased neuroinflammation with APOE4 and AD.
Keyphrases
- cognitive decline
- high fat diet
- oxidative stress
- lipopolysaccharide induced
- traumatic brain injury
- lps induced
- cognitive impairment
- mild cognitive impairment
- cerebral ischemia
- dna damage
- type diabetes
- metabolic syndrome
- induced apoptosis
- endoplasmic reticulum stress
- adverse drug
- diabetic rats
- brain injury
- blood brain barrier
- skeletal muscle
- heat shock
- risk assessment
- heat stress