Feasibility of a mini-pig model of radiation-induced brain injury to one cerebral hemisphere.

Ilektra AthanasiadiWhitney D PerezJeannie M PlantengaYava Jones-HallCarlos J Perez-Torres

Published in: Radiation oncology (London, England) (2021)

Based on our results, a mini-pig model of radiation-induced brain injury is feasible though some optimization is still needed. The mini-pig model produced lesions on MRI that are consistent with the human disease and which are not seen in rodent models. Our data shows that the ideal radiation dose for this model likely lies between 15 and 25 Gy.

Keyphrases

brain injury
radiation induced
subarachnoid hemorrhage
radiation therapy
cerebral ischemia
magnetic resonance imaging
endothelial cells
magnetic resonance
big data
blood brain barrier