Nicotine Rather Than Non-Nicotine Substances in 3R4F WCSC Increases Behavioral Sensitization and Drug-Taking Behavior in Rats.
Sunghyun KimSumin SohnIn Soo RyuJu Hwan YangOc-Hee KimJi Sun KimYong-Hyun KimEun Young JangEun Sang ChoePublished in: Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco (2022)
WCSC does not augment the nicotine-induced increases in behavioral sensitization, drug-taking behavior, and glutamate and dopamine concentrations, suggesting that non-nicotine substances do not potentiate the nicotine-induced behaviors by increasing the concentrations of the neurotransmitters in the CPu. These findings imply that nicotine, but not non-nicotine substances in WCSC, may be a major contributor that induces tobacco dependence in rats.