A recent overview on the synthesis of 1,4,5-trisubstituted 1,2,3-triazoles.

Diverse strategies for the efficient and attractive synthesis of a wide variety of relevant 1,4,5-trisubstituted 1,2,3-triazole molecules are reported. The synthesis of this category of diverse fully functionalized 1,2,3-triazoles has become a necessary and unique research subject in modern synthetic organic key transformations in academia, pharmacy, and industry. The current review aims to cover a wide literature survey of numerous synthetic strategies. Recent reports (2017-2021) in the field of 1,4,5-trisubstituted 1,2,3-triazoles are emphasized in this current review.