Use of circulating tumoral DNA to guide treatment for metastatic melanoma.
Guillaume HerbreteauSandrine CharpentierAudrey ValléeMarc Guillaume DenisPublished in: Pharmacogenomics (2019)
The management of metastatic cutaneous melanoma is conditioned by the identification of BRAF-activating mutations in tumor DNA. Tumor genotyping is usually performed on DNA extracted from tissue samples. However, these invasive samples are rarely repeated during follow-up, and their analysis requires a sample pre-treatment which may take several weeks. Circulating tumor DNA (ctDNA), released into blood by cancer cells, is a good alternative to tissue sampling. ctDNA is not subject to tumor heterogeneity, and can be analyzed rapidly, making possible the detection of mutations in emergency or in patients whose tumor cannot be sampled. ctDNA can also be analyzed repeatedly during follow-up, for postresection minimal residual disease assessment, for therapeutic response monitoring and for early relapse detection.
Keyphrases
- circulating tumor
- cell free
- circulating tumor cells
- end stage renal disease
- squamous cell carcinoma
- healthcare
- chronic kidney disease
- emergency department
- small cell lung cancer
- public health
- ejection fraction
- signaling pathway
- single molecule
- newly diagnosed
- peritoneal dialysis
- patient reported outcomes
- skin cancer