Molecular diagnosis of bacteremia in a pediatric intensive care unit: a step forward.
Iker Falces-RomeroCarmen Román-HernándezCristina Schuffelmann-GutiérrezMaría Laplaza-GonzálezLuis Escosa-GarcíaIván BloiseMaría P Romero-GómezCristina Verdú-SánchezBelén Calderón-LlopisIrene Amores-HernándezAna Gómez-ZamoraMiguel Río-GarcíaJuan J Menéndez-SusoDiego Rodríguez-ÁlvarezElena Pérez-AcostaMiguel Rodríguez-RubioElena Álvarez-RojasPedro de la OlivaJesús MingorancePaloma D Martínez-RomilloJulio García-RodríguezEmilio Cendejas-BuenoPublished in: Future microbiology (2022)
Aim: T2Bacteria ® Panel detects six ESKAPE pathogens in around 3.5 h directly in whole blood. Our aim was to compare T2Bacteria with simultaneous blood culture in critically ill children with suspected bloodstream infection. Materials & methods: Retrospective study of critically ill children admitted to our tertiary-care center (2018-2020). Results: A total of 60 patients were recruited, including 63 episodes and 75 T2Bacteria/blood cultures were performed. Overall agreement between T2Bacteria and blood culture was 78.7% with a discordance of 21.3% (16/75 samples). Conclusion: T2Bacteria Panel may be useful in critically ill children providing an accurate and fast diagnosis of bacteremia directly from blood sample and detecting pathogens not recovered in blood cultures.