Synovial Tissue Heterogeneity in Japanese Patients with Rheumatoid Arthritis Elucidated Using a Cell-Type Deconvolution Approach.

Sotaro NakajimaHaruka TsuchiyaMineto OtaMegumi OgawaSaeko YamadaRyochi YoshidaJunko MaedaHarumi ShiraiTaro KasaiJun HiroseKeita Ninagawa Yuichiro FujiedaTakeshi IwasakiYoshimi AizakiHiroshi KajiyamaMasakazu MatsushitaEiryo KawakamiNaoto TamuraToshihide MimuraKoichiro OhmuraAkio MorinobuTatsuya AtsumiYoshiya Tanaka Tsutomu Takeuchi Sakae TanakaTomohisa OkamuraKeishi Fujio

Published in: Arthritis & rheumatology (Hoboken, N.J.) (2023)

This study adds insights into the synovial heterogeneity in Japanese patients, and shows a promising link with predominant inflammatory signals. Evaluating the site of inflammation has the potential to lead to appropriate drug selection that matches the individual pathology. This article is protected by copyright. All rights reserved.

Keyphrases

oxidative stress
single cell
emergency department
human health
risk assessment
adverse drug