Facilitating drug delivery in the central nervous system by opening the blood-cerebrospinal fluid barrier with a single low energy shockwave pulse.

Yi KungKuan-Yu ChenWei-Hao LiaoYi-Hua HsuChueh-Hung WuMing-Yen HsiaoAbel P-H HuangWen-Shiang Chen

Published in: Fluids and barriers of the CNS (2022)

This is the first study to demonstrate and validate a method for noninvasively and selectively opening the BCSFB to enhance drug delivery into CSF circulation. Potential applications may include treatments for neurodegenerative diseases, CNS infections, brain tumors, and leptomeningeal carcinomatosis.

Keyphrases

cerebrospinal fluid
drug delivery
cancer therapy
blood pressure
drug release
risk assessment
climate change