Evolutionary patterns of chromosomal instability and mismatch repair deficiency in proximal and distal colorectal cancer.

Mariola Monika GolasBastian GunawanMeliha CakirSilke CameronChristina EndersTorsten LierschLaszlo FüzesiBjoern Sander

Published in: Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland (2021)

CRCs characterized by CIN follow multiple, interconnected genetic pathways in line with the basic 'Vogelgram' concept proposed for the progression of CRC that places the accumulation of genetic changes at centre of tumour evolution. However, the timing of specific genetic events may favour metastatic potential.

Keyphrases

genome wide
copy number
small cell lung cancer
squamous cell carcinoma
dna methylation
gene expression
risk assessment
climate change