A multifaceted investigation into molecular associations of chronic thromboembolic pulmonary hypertension pathogenesis.
Stephen J HallidayDaniel T MatthewsMegha H TalatiEric D AustinYan R SuTarek S AbsiNiki L FortuneDavid GailaniAnton MatafonovJames D WestAnna R HemnesPublished in: JRSM cardiovascular disease (2020)
Our data do not support impaired clot lysis underlying chronic thromboembolic pulmonary hypertension, but did demonstrate distinct molecular patterns present both in peripheral blood and in pathologic specimens of chronic thromboembolic pulmonary hypertension patients suggesting that altered metabolism may play a role in chronic thromboembolic pulmonary hypertension pathogenesis.