A pilot phase Ib study to evaluate tadalafil to overcome immunosuppression during chemoradiotherapy for IDH-wild-type glioblastoma.

Subhajit GhoshTanner M JohannsMilan G ChhedaEric LiuOmar ButtChristopher AbrahamShahed BadiyanYi HuangDavid DeNardoAlbert H KimDennis HallahanDinesh Thotala Jiayi Huang

Published in: Neuro-oncology advances (2023)

Concurrent tadalafil is well tolerated during chemoradiotherapy for GBM. Tadalafil is associated with a reduction of peripheral MDSCs after chemoradiotherapy and increased CD8 T-cell proliferation and activation.

Keyphrases

locally advanced
wild type
rectal cancer
lower urinary tract symptoms
cell proliferation
benign prostatic hyperplasia
squamous cell carcinoma
radiation therapy
cell cycle
low grade
study protocol
chemotherapy induced
nk cells