Increased Th22 cell numbers in a general pediatric population with filaggrin haploinsufficiency: The Generation R Study.
Kirsten I M LoomanMinke M F van MierloMenno C van ZelmChen HuLiesbeth DuijtsJohan C de JongsteTamar E C NijstenLuba M PardoJessica Christina Kiefte-de JongHenriette A MollSuzanne G M A PasmansPublished in: Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology (2021)
School-aged children of a general population with FLG mutations have higher Th22 cell numbers, which reflects the immunological response to the skin barrier dysfunction. FLG mutations did not otherwise affect the composition of the adaptive immunity in this general pediatric population.