Cytotoxic T lymphocytes from cattle sharing the same MHC class I haplotype and immunized with live Theileria parva sporozoites differ in antigenic specificity.
Lucilla SteinaaNicholas SvitekElias AwinoRosemary SayaPhilip ToyePublished in: BMC research notes (2018)
The antigenic specificity of CTL from MHC class I-matched cattle vaccinated with the Muguga cocktail were different. Three cattle of MHC class I haplotype A18, one A18/A19 and two haploidentical (A18v/A12) animals, showed differential recognition of autologous cells infected with a panel of T. parva isolates. This could have implications in the field where certain strains could break through the vaccine. Furthermore, neither of the haploidentical cattle recognized the CTL epitope (Tp1214-224), presented by the A18 haplotype, in contrast to the third animal, showing differences in immunodominance in animals of the same haplotype A18. This suggests that the CTL specificities following immunization with the Muguga cocktail can vary even between haploidentical individuals and that some parasite strains may break through immunity generated by the Muguga cocktail.
Keyphrases
- bone marrow
- stem cell transplantation
- peripheral blood
- escherichia coli
- induced apoptosis
- cord blood
- magnetic resonance
- cell cycle arrest
- healthcare
- magnetic resonance imaging
- health information
- oxidative stress
- cell therapy
- computed tomography
- signaling pathway
- cell death
- endoplasmic reticulum stress
- monoclonal antibody