Long-term beneficial effect of faecal microbiota transplantation on colonisation of multidrug-resistant bacteria and resistome abundance in patients with recurrent Clostridioides difficile infection.
Sam NooijKaruna E W VendrikRomy D ZwittinkQuinten R DucarmonJosbert J KellerEd J KuijperElisabeth M Terveernull nullPublished in: Genome medicine (2024)
Taken together, we hypothesise that FMT restores the gut microbiota to a composition that is closer to the composition of healthy donors, and potential pathogens are either lost or decreased to very low abundances. This process, however, does not end in the days following FMT. It may take months for the gut microbiome to re-establish a balanced state. Even though a reservoir of resistance genes remains, a notable part of which on plasmids, FMT decreases the total load of resistance genes.
Keyphrases
- multidrug resistant
- gram negative
- genome wide
- clostridium difficile
- klebsiella pneumoniae
- bioinformatics analysis
- genome wide identification
- escherichia coli
- acinetobacter baumannii
- genome wide analysis
- stem cells
- antibiotic resistance genes
- antimicrobial resistance
- climate change
- transcription factor
- human health
- pseudomonas aeruginosa
- wastewater treatment