NLRP3 inflammasome is involved in testicular inflammation induced by lipopolysaccharide in mice.
Michiya SanoHiromu KomiyamaRiina ShinodaRen OzawaHiroyuki WatanabeTadayoshi KarasawaMasafumi TakahashiYasushi ToriiHisataka IwataTakehito KuwayamaKoumei ShirasunaPublished in: American journal of reproductive immunology (New York, N.Y. : 1989) (2022)
Taken together, our results suggest that testicular cells have the potential to secrete IL-1β and CCL2 in an NLRP3 inflammasome-dependent manner and that these cytokines from the testis may further exacerbate testicular function, resulting in subfertility during infectious diseases.
Keyphrases
- nlrp inflammasome
- germ cell
- infectious diseases
- induced apoptosis
- oxidative stress
- cell cycle arrest
- inflammatory response
- toll like receptor
- high fat diet induced
- lps induced
- endoplasmic reticulum stress
- cell death
- type diabetes
- immune response
- climate change
- adipose tissue
- metabolic syndrome
- wild type
- insulin resistance