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NLRP3 inflammasome is involved in testicular inflammation induced by lipopolysaccharide in mice.

Michiya SanoHiromu KomiyamaRiina ShinodaRen OzawaHiroyuki WatanabeTadayoshi KarasawaMasafumi TakahashiYasushi ToriiHisataka IwataTakehito KuwayamaKoumei Shirasuna
Published in: American journal of reproductive immunology (New York, N.Y. : 1989) (2022)
Taken together, our results suggest that testicular cells have the potential to secrete IL-1β and CCL2 in an NLRP3 inflammasome-dependent manner and that these cytokines from the testis may further exacerbate testicular function, resulting in subfertility during infectious diseases.
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