High homogeneity of mismatch repair deficiency in advanced prostate cancer.

Christoph FrauneRonald SimonDoris HöflmayerKatharina MöllerDavid DumFranziska BüscheckClaudia Hube-MaggGeorgia Makrypidi-FrauneMartina KluthAndrea HinschEike BurandtTill Sebastian ClauditzWaldemar WilczakGuido SauterStefan Steurer

Published in: Virchows Archiv : an international journal of pathology (2019)

The absence of intratumoral heterogeneity for the MMR status suggests that MSI occurs early in prostate cancer. It is concluded that MMR analysis on limited biopsy material by IHC is sufficient to estimate the MMR status of the entire cancer mass.

Keyphrases

prostate cancer
radical prostatectomy
papillary thyroid
single cell
squamous cell
ultrasound guided
fine needle aspiration
childhood cancer