Dynamics of scFv-targeted VAP2 correlating with IL-16, MIF and IL-1Ra in ANCA-associated vasculitis.

Junya SuzukiShunsuke FurutaYosuke KameokaOsamu SuzukiFuyu ItoKazuko UnoFukuko KishiYoshio YamakawaKazuyuki MatsushitaTakashi MikiHiroshi NakajimaKazuo Suzuki

Published in: Microvascular research (2024)

The 24 kDa VAP2 molecule may be associated with neutrophil functions because of its inverse correlation with MPO activity, IL-16, MIF, and IL-1Ra, suggesting that VAP2-APOA1 formation in HDL triggers microvascular injury. VasSF may reverse the injury by removing APOA1-VAP2 heterodimers from peripheral blood vessels.

Keyphrases

peripheral blood
rheumatoid arthritis
disease activity
systemic sclerosis
systemic lupus erythematosus
heat shock protein
interstitial lung disease