Autophagy Reduces the Degradation and Promotes Membrane Localization of Occludin to Enhance the Intestinal Epithelial Tight Junction Barrier against Paracellular Macromolecule Flux.

Kushal SahaAshwinkumar Subramenium GanapathyAlexandra WangNathan Michael MorrisEric SuchanecWei DingGregory YochumWalter KoltunMeghali NighotThomas MaPrashant Nighot

Published in: Journal of Crohn's & colitis (2022)

Our data suggest a novel role of autophagy in promoting the intestinal TJ barrier by increasing occludin levels in an ERK1/2 MAPK-dependent mechanism.

Keyphrases

signaling pathway
pi k akt
oxidative stress
cell death
endoplasmic reticulum stress
cell proliferation
big data
machine learning
artificial intelligence
data analysis