Claudin-1 as a novel target gene induced in obesity and associated to inflammation, fibrosis and cell differentiation.
Pablo Fernández-GarcíaSiri D TaxeråsMarjorie Reyes-FariasLorena GonzálezAndrea Soria-GondekSilvia PelliteroJordi TarascóPau MorenoLauro SumoyJacqueline M StephensLindsey G YooMaría GalánAdriana IzquierdoGema Medina-GómezLaura HerreroPatricia CorralesFrancesc VillarroyaRubén CereijoDavid Sanchez-InfantesPublished in: European journal of endocrinology (2024)
These results suggest CLDN1 is a novel marker induced in obesity, and differentially expressed in T lymphocytes infiltrated in human vWAT as compared to sWAT. This protein may have a crucial role in the crosstalk between T lymphocytes and other adipose tissue cells and may contribute to inflammation, fibrosis and alter homeostasis and promote metabolic disease in obesity.
Keyphrases
- insulin resistance
- adipose tissue
- metabolic syndrome
- weight loss
- high fat diet induced
- high glucose
- oxidative stress
- type diabetes
- endothelial cells
- diabetic rats
- weight gain
- induced apoptosis
- high fat diet
- skeletal muscle
- genome wide
- cell cycle arrest
- copy number
- physical activity
- small molecule
- signaling pathway
- amino acid