Chromosome contacts in activated T cells identify autoimmune disease candidate genes.

Oliver S BurrenArcadio Rubio GarcíaBiola-Maria JavierreDaniel B RainbowJonathan CairnsNicholas J CooperJohn J LambourneEllen SchofieldXaquin Castro DopicoRicardo C FerreiraRichard CoulsonFrances BurdenSophia P RowlstonKate DownesSteven W WingettMattia FrontiniWillem H OuwehandPeter FraserMikhail SpivakovJohn A ToddLinda S WickerAntony J CutlerChris Wallace

Published in: Genome biology (2017)

Our systematic experimental framework offers an alternative approach to candidate causal gene identification for variants with cell state-specific functional effects, with achievable sample sizes.

Keyphrases

copy number
single cell
genome wide
multiple sclerosis
cell therapy
dna methylation
stem cells
gene expression
bioinformatics analysis
mesenchymal stem cells