Assessing for interaction between APOE ε4, sex, and lifestyle on cognitive abilities.
Donald M LyallCarlos Celis-MoralesLaura M LyallChristopher GrahamNicholas GrahamDaniel F MackayRona Juliette StrawbridgeJoey WardJason M R GillNaveed SattarJonathan CavanaghDaniel J SmithJill P PellPublished in: Neurology (2019)
Our results do not provide support for the idea that ε4 genotype increases vulnerability to the negative effects of lifestyle risk factors on cognitive ability, but rather support a primarily outright association between APOE ε4 genotype and worse cognitive ability.