Assessing for interaction between APOE ε4, sex, and lifestyle on cognitive abilities.

Donald M LyallCarlos Celis-MoralesLaura M LyallChristopher GrahamNicholas GrahamDaniel F MackayRona Juliette StrawbridgeJoey WardJason M R GillNaveed SattarJonathan CavanaghDaniel J SmithJill P Pell

Published in: Neurology (2019)

Our results do not provide support for the idea that ε4 genotype increases vulnerability to the negative effects of lifestyle risk factors on cognitive ability, but rather support a primarily outright association between APOE ε4 genotype and worse cognitive ability.

Keyphrases

risk factors
metabolic syndrome
cognitive decline
physical activity
cardiovascular disease
high fat diet
climate change
skeletal muscle
insulin resistance
mild cognitive impairment