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Assessing for interaction between APOE ε4, sex, and lifestyle on cognitive abilities.

Donald M LyallCarlos Celis-MoralesLaura M LyallChristopher GrahamNicholas GrahamDaniel F MackayRona Juliette StrawbridgeJoey WardJason M R GillNaveed SattarJonathan CavanaghDaniel J SmithJill P Pell
Published in: Neurology (2019)
Our results do not provide support for the idea that ε4 genotype increases vulnerability to the negative effects of lifestyle risk factors on cognitive ability, but rather support a primarily outright association between APOE ε4 genotype and worse cognitive ability.
Keyphrases
  • risk factors
  • metabolic syndrome
  • cognitive decline
  • physical activity
  • cardiovascular disease
  • high fat diet
  • climate change
  • skeletal muscle
  • insulin resistance
  • mild cognitive impairment