Revolutionizing Hyperlipidemia Treatment: Nanoencapsulated CoQ10 and Selenium Combat Simvastatin-Induced Myopathy and Insulin Resistance in Rats.

Hagar B Abo-ZalamEzz El Deen El DensharyRania A AbdalsalamIslam A KhalilMahmoud M KhattabMohamed A Hamzawy

Published in: Advanced pharmaceutical bulletin (2023)

These findings suggest that the CoQNPs or SeNPs platforms offer advanced relief for hyperlipidemia and insulin resistance while limiting adverse effects such as myopathy and hepatotoxicity.

Keyphrases

high fat diet
insulin resistance
late onset
high fat diet induced
drug induced
adipose tissue
high glucose
metabolic syndrome
type diabetes
muscular dystrophy
diabetic rats
skeletal muscle
oxidative stress
combination therapy
endothelial cells