Diagnosing hereditary cancer predisposition in men with prostate cancer.
Mary PritzlaffYuan TianPatrick ReinekeA J StuenkelKyle AllenStephanie GutierrezMichelle JacksonJill S DolinskyHolly LaDucaJianfeng XuMary Helen BlackBrian T HelfandPublished in: Genetics in medicine : official journal of the American College of Medical Genetics (2020)
These results support multigene panel testing as the primary genetic testing approach for hereditary prostate cancer and are supportive of recommendations for consideration of germline testing in men with prostate cancer. Expanding the criteria for genetic testing should be considered as many pathogenic variants are actionable for treatment of advanced prostate cancer.