Long-range genomic regulators of THBS1 and LTBP4 modify disease severity in duchenne muscular dystrophy.

Robert B WeissVeronica J VielandDiane M DunnYuuki KaminohKevin M Flanigannull null

Published in: Annals of neurology (2018)

Together with previous evidence implicating LTBP4, the THBS1 modifier locus emphasizes the role that common regulatory variants in gene interaction networks can play in mitigating disease progression in muscular dystrophy. Ann Neurol 2018;84:234-245.

Keyphrases

duchenne muscular dystrophy
muscular dystrophy
copy number
transcription factor
genome wide
dna methylation
genome wide identification
gene expression