Neuroprotective epi-drugs quench the inflammatory response and microglial/macrophage activation in a mouse model of permanent brain ischemia.
Mariana MotaVanessa PorriniEdoardo ParrellaMarina BenareseArianna BellucciSina RheinMarkus SchwaningerMarina PizziPublished in: Journal of neuroinflammation (2020)
Our findings indicate that single treatment with MS-275 and resveratrol can reduce stroke-mediated brain injury and inflammation observed 2 days after the pMCAO and put the rational to test repeated administration of the drugs. The anti-inflammatory property of MS-275 and resveratrol combination can be ascribed to both primary direct inhibition of microglia/macrophage activation and secondary glial/macrophages inhibition mediated by neuroprotection.
Keyphrases
- brain injury
- cerebral ischemia
- inflammatory response
- subarachnoid hemorrhage
- mouse model
- lipopolysaccharide induced
- mass spectrometry
- neuropathic pain
- lps induced
- multiple sclerosis
- anti inflammatory
- ms ms
- toll like receptor
- adipose tissue
- blood brain barrier
- oxidative stress
- atrial fibrillation
- white matter
- spinal cord
- immune response
- combination therapy
- functional connectivity