Whole-Genome Sequences of Burkholderia pseudomallei Isolates Exhibiting Decreased Meropenem Susceptibility.

Erin P PriceMelissa Laird SmithEllen E PaxinosLuke J TallonLisa SadzewiczNaomi SengamalayRobert W BairdBart J CurrieDerek S Sarovich

Published in: Genome announcements (2017)

We report here paired isogenic Burkholderia pseudomallei genomes obtained from three patients receiving intravenous meropenem for melioidosis treatment, with post-meropenem isolates developing decreased susceptibility. Two genomes were finished, and four were drafted to improved high-quality standard. These genomes will be used to identify meropenem resistance mechanisms in B. pseudomallei.

Keyphrases

gram negative
genetic diversity
multidrug resistant
high dose
low dose
replacement therapy