Landscape of immune-related signatures induced by targeting of different epigenetic regulators in melanoma: implications for immunotherapy.

Alessandro DesideriAlessandra MollaGabriella NicoliniValentina Eleonora PerottiFrancesco SgambelluriAlessia CovreCarolina FazioMaria Fortunata LofiegoAnna Maria Di GiacomoSandra CoralAntonella MancaMaria Cristina SiniMarina PisanoTeresa NovielloFrancesca CarusoSilvia BrichGiancarlo PruneriAndrea MaurichiMario SantinamiMichele CeccarelliGiuseppe PalmieriMichele MaioRoberta Mortarininull null

Published in: Journal of experimental & clinical cancer research : CR (2022)

The DNMT inhibitor guadecitabine emerged as the most promising immunomodulatory agent among those tested, supporting the rationale for usage of this class of epigenetic drugs in combinatorial immunotherapy approaches.

Keyphrases

dna methylation
genome wide
gene expression
transcription factor
clinical trial
cancer therapy
drug induced
skin cancer