A novel microbial and hepatic biotransformation-integrated network pharmacology strategy explores the therapeutic mechanisms of bioactive herbal products in neurological diseases: the effects of Astragaloside IV on intracerebral hemorrhage as an example.
En HuZhilin LiTeng LiXueping YangRuoqi DingHaoying JiangHong SuMenghan ChengZhe YuHaigang LiTao TangYang WangPublished in: Chinese medicine (2023)
ASIV inhibits post-ICH microglia/macrophage proliferation and migration, probably through its transformed products to bind CDC42, PTK2, and CSF1R. The integrated strategy can be used to discover novel mechanisms of herbal products or traditional Chinses medicine in treating diseases.