SPOP-mediated ubiquitination and degradation of PDK1 suppresses AKT kinase activity and oncogenic functions.
Qiwei JiangNana ZhengLang BuXiaomei ZhangXiaoling ZhangYuanzhong WuYaqing SuLei WangXiaomin ZhangShancheng RenXiangpeng DaiDepei WuWei XieWenyi WeiYasheng ZhuJian-Ping GuoPublished in: Molecular cancer (2021)
Our results not only reveal a physiological regulation of PDK1 by E3 ligase SPOP, but also highlight the oncogenic roles of loss-of-function mutations of SPOP or gain-of-function mutations of PDK1 in tumorigenesis through activating the AKT kinase.