Effective normalization for copy number variation in Hi-C data.

Nicolas ServantNelle VaroquauxEdith HeardEmmanuel BarillotJean-Philippe Vert

Published in: BMC bioinformatics (2018)

Taken together, our results highlight the importance of using dedicated methods for the analysis of Hi-C cancer data. Both CAIC and LOIC methods perform well on simulated and real Hi-C data sets, each fulfilling different needs.

Keyphrases

copy number
electronic health record
mitochondrial dna
big data
genome wide
dna methylation
papillary thyroid
squamous cell carcinoma
gene expression
young adults