Rosmarinic acid, a natural polyphenol, has a potential pro-oxidant risk via NADH-mediated oxidative DNA damage.

Hatasu KobayashiYuichiro HiraoShosuke KawanishiShinya KatoYurie MoriMariko MurataShinji Oikawa

Published in: Genes and environment : the official journal of the Japanese Environmental Mutagen Society (2024)

In this study, physiologically relevant concentrations of RA effectively induced oxidative DNA damage in isolated DNA through redox cycle reactions with copper and NADH.

Keyphrases

dna damage
oxidative stress
dna repair
anti inflammatory
rheumatoid arthritis
diabetic rats
high glucose
systemic lupus erythematosus
disease activity
ankylosing spondylitis
drug induced
idiopathic pulmonary fibrosis