Clinically relevant model of oxaliplatin-induced sinusoidal obstruction syndrome.

Rei TodaSatoru SeoYusuke UemotoKoshiro MorinoHiroto NishinoNaohiko NakamuraMasayuki OkunoKohta IguchiMotohiko SatoKojiro NakamuraKojiro TauraShunsaku NakagawaTakayuki NakagawaTatsuaki TsuruyamaToshiaki ManabeHiroaki KawaguchiKeiko IwaisakoMasaya IkegawaShinji UemotoEtsuro Hatano

Published in: Hepatology research : the official journal of the Japan Society of Hepatology (2022)

With distinct differences between monocrotaline-induced rat SOS and human/pig OXCx-SOS, our pig OXCx-SOS model serves as a preclinical platform for future investigations to dissect the pathophysiology of OXCx-SOS and seek preventive strategies.

Keyphrases

high glucose
endothelial cells
diabetic rats
pulmonary hypertension
oxidative stress
drug induced
stem cells
case report
current status
induced pluripotent stem cells
stress induced