Cancer occurrence in Turner syndrome and the effect of sex hormone substitution therapy.
Mette Hansen ViuffKirstine StochholmAngela LinAgnethe BerglundSvend JuulClaus Højbjerg GravholtPublished in: European journal of endocrinology (2020)
The lack of one X chromosome might play a role in skin neoplasms, CNS tumors, colon and rectal cancers. The risk of breast cancer is lower than in the general population. Long-term HRT during the premenopausal age range seems not to exert a cancerous effect in Turner syndrome. Increased vigilance concerning specific types of cancer in Tuner syndrome harboring a 45,X karyotype is needed.