Prognostic significance of promoter CpG island methylation of obesity-related genes in patients with nonmetastatic renal cell carcinoma.

Julia Mendoza-PérezJian GuLuis A HerreraNizar M TannirShanyu ZhangSurena MatinJose Antonio KaramChristopher G WoodXifeng Wu

Published in: Cancer (2017)

Somatic alterations of promoter methylation in the NPY, LEP, and LEPR genes are involved in RCC tumorigenesis. Furthermore, LEPR methylation appears to be associated with RCC recurrence. Future research to elucidate the biology underlying this association is warranted. Cancer 2017;123:3617-27. © 2017 American Cancer Society.

Keyphrases

dna methylation
renal cell carcinoma
genome wide
papillary thyroid
gene expression
squamous cell
transcription factor
metabolic syndrome
insulin resistance
lymph node metastasis
squamous cell carcinoma
weight gain
adipose tissue
skeletal muscle
free survival