A close shave: How SARS-CoV-2 induces the loss of cilia.

Published in: The Journal of cell biology (2022)

Wang et al. report in this issue (2022. J. Cell Biol.https://doi.org/10.1083/jcb.202108015) that the SARS-CoV-2 protein ORF10 increases the activity of the E3 ligase CUL2ZYG11B, leading to the degradation of multiple ciliary proteins. The resulting loss of cilia may facilitate the spread of SARS-CoV-2 in the respiratory tree.

Keyphrases

sars cov
respiratory syndrome coronavirus
single cell
cell therapy
stem cells
binding protein
coronavirus disease
bone marrow
small molecule