Altered large-scale individual-based morphological brain network in spinocerebellar ataxia type 3.

Shu SuRunhua ShaHaishan QiuJianping ChuLiping LinLong QianManshi HuChao WuGerald L CheungZhiyun YangYingqian Chen Jing Zhao

Published in: CNS neuroscience & therapeutics (2023)

Symptomatic SCA3 patients undergo an extensive and significant reorganization in large-scale individual-based MBNs, probably due to disrupted prefrontal cortico-striato-thalamo-cortical loops, limbic-striatum circuitry, and enhanced connectivity in the neostriatum. This study highlights the crucial role of abnormal morphological connectivity alterations beyond the pattern of brain atrophy, which might pave the way for therapeutic development in the future.

Keyphrases

resting state
functional connectivity
white matter
end stage renal disease
ejection fraction
newly diagnosed
chronic kidney disease
multiple sclerosis
peritoneal dialysis
prognostic factors
working memory
current status
transcranial magnetic stimulation
early onset
high frequency
patient reported