The adsorption of dabigatran is as efficient as addition of idarucizumab to neutralize the drug in routine coagulation assays.

Marc G JacqueminJ ToelenL FeyenJ SchoetersI Van HorenbeeckI VanlinthoutM DebasseT VanasscheK PeerlinckP Verhamme

Published in: International journal of laboratory hematology (2018)

Adsorption of dabigatran in plasma samples containing the drug neutralizes its activity as efficiently as the addition of idarucizumab. This method allows the evaluation of thrombophilia markers without interruption of anticoagulation therapy or the detection of hemostasis disorders in patients treated with the drug.

Keyphrases

atrial fibrillation
adverse drug
venous thromboembolism
high throughput
drug induced
clinical practice
bone marrow
loop mediated isothermal amplification
label free
quantum dots
cell therapy