Non-HDL-C/TG ratio indicates significant underestimation of calculated low-density lipoprotein cholesterol (LDL-C) better than TG level: a study on the reliability of mathematical formulas used for LDL-C estimation.

Agnieszka ĆwiklińskaEwa WieczorekAnna GliwińskaMarta MarcinkowskaMonika CzaplińskaAgnieszka MickiewiczAgnieszka KuchtaBarbara Kortas-StempakMarcin GruchałaAlicja Dębska-ŚlizieńEwa KrólMaciej Jankowski

Published in: Clinical chemistry and laboratory medicine (2020)

The Martin/Hopkins, Vujovic and Sampson formulas appear to be more accurate than the Friedewald formula. To minimize the number of significantly underestimated LDL-C results, we propose the implementation of risk categories according to non-HDL-C/TG ratio and suggest that for samples with a non-HDL-C/TG ratio of <1.2, the LDL-C level should not be calculated but measured independently from TG level.

Keyphrases

low density lipoprotein
healthcare
primary care
high resolution
human milk
mass spectrometry
low birth weight
breast cancer risk