Human Leukocyte Antigen DQ (HLA-DQ) genotypes and haplotypes and their association with phenotype in patients with celiac disease in India.

Balakrishnan Siddartha RamakrishnaGiriprasad VenugopalAlka SinghSrinivasan PugazhendhiSangitanjan DuttaVineet AhujaGovind K Makharia

Published in: JGH open : an open access journal of gastroenterology and hepatology (2021)

HLA-DQA1*05:01 ~ HLA-DQB1*02:01 (haplotype DQ2.5) showed a very strong risk association with symptomatic CeD in Indian patients. The strength of association showed a gradient of increase from potential to typical CeD, coinciding with a phenotypic change in the celiac iceberg.

Keyphrases

celiac disease
end stage renal disease
ejection fraction
endothelial cells
patient reported outcomes
peripheral blood
patient reported