Histone Demethylation and Toll-like Receptor 8-Dependent Cross-Talk in Monocytes Promotes Transdifferentiation of Fibroblasts in Systemic Sclerosis Via Fra-2.

Marzena CiechomskaSteven O'ReillyStefan PrzyborskiFiona OakleyKatarzyna Bogunia-KubikJacob M van Laar

Published in: Arthritis & rheumatology (Hoboken, N.J.) (2017)

These data demonstrate a novel role of histone demethylation induced by DZNep on Fra-2-mediated TIMP-1 production by monocytes in the presence of TLR-8 agonist. This consequently orchestrates the transdifferentiation of fibroblasts, a key event in the pathogenesis of SSc.

Keyphrases

toll like receptor
systemic sclerosis
interstitial lung disease
nuclear factor
inflammatory response
dna methylation
extracellular matrix
immune response
dendritic cells
peripheral blood
electronic health record
big data
gene expression
machine learning
rheumatoid arthritis
deep learning