Selective Endothelial Hyperactivation of Oncogenic KRAS Induces Brain Arteriovenous Malformations in Mice.
Eun S ParkSehee KimShuning HuangJi Young YooJakob KörbelinTae Jin LeeBalveen KaurPramod K DashPeng Roc ChenEunhee KimPublished in: Annals of neurology (2021)
Our innovative approach using AAV-BR1 confirms that KRAS mutations promote bAVM development via the MEK/ERK pathway, and provides a novel preclinical mouse model of bAVMs which will be useful to develop a therapeutic strategy for patients with bAVM. ANN NEUROL 2021;89:926-941.
Keyphrases
- wild type
- mouse model
- pi k akt
- signaling pathway
- white matter
- cell proliferation
- resting state
- endothelial cells
- high fat diet induced
- transcription factor
- gene therapy
- cell therapy
- neural network
- stem cells
- cerebral ischemia
- adipose tissue
- type diabetes
- mesenchymal stem cells
- bone marrow
- skeletal muscle
- insulin resistance
- blood brain barrier
- brain injury