Effects of Two Soluble ACE2-Fc Variants on Blood Pressure and Albuminuria in Hypertensive Mice: Research Letter.
Mayra Trentin-SonodaJoseph ZimpelmannKarishma TailorJohn W GillardNathan YoganathanTraian SuleaKevin D BurnsPublished in: Canadian journal of kidney health and disease (2023)
Soluble ACE2-Fc variant K reduces blood pressure and tends to lower albuminuria in hypertensive mice. Furthermore, soluble ACE2-Fc variant K has prolonged tissue retention, associated with increased tissue ACE2 activity. The results support further studies directed at the therapeutic potential of soluble ACE2-Fc variant K for cardiovascular and kidney protection.