Adenosine deficiency facilitates CA1 synaptic hyperexcitability in the presymptomatic phase of a knock in mouse model of Alzheimer's disease.
Mattia BonzanniAlice BragaTakashi SaitoTakaomi C SaidoGiuseppina TescoPhilip G HaydonPublished in: bioRxiv : the preprint server for biology (2024)
Reduced adenosine tone is driven by reduced ATP-to-adenosine extracellular conversionRestoration of adenosine tone successfully normalizes neuronal excitability in the AD model.