Construction and analysis of a lncRNA (PWRN2)-mediated ceRNA network reveal its potential roles in oocyte nuclear maturation of patients with PCOS.

Xin HuangJiaping PanBi WuXiaoming Teng

Published in: Reproductive biology and endocrinology : RB&E (2018)

PWNR2 plays important roles in oocyte nuclear maturation in PCOS by functioning as a ceRNA to reduce the availability of miR-92b-3p for TMEM120B target binding during oocyte maturation in PCOS. Our findings would provide new information and clarify abnormal oocyte development in PCOS.

Keyphrases

polycystic ovary syndrome
long non coding rna
insulin resistance
genome wide
metabolic syndrome
single cell
gene expression
dna methylation