Landscape of Human Immunodeficiency Virus Neutralization Susceptibilities Across Tissue Reservoirs.

Chuangqi WangTimothy E SchlubWen Han YuC Sabrina TanKarl SteficSara GianellaDavey M SmithDouglas A LauffenburgerAntoine ChaillonBoris Julg

Published in: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America (2022)

Blood-based screening methods to determine viral susceptibility to bNAbs might underestimate the presence of resistant viral variants in tissues. The extent to which these resistant viruses are clinically relevant, that is, lead to bNAb therapeutic failure, needs to be further explored.

Keyphrases

human immunodeficiency virus
hepatitis c virus
sars cov
antiretroviral therapy
hiv infected
hiv aids
copy number
hiv positive
single cell
dna methylation
genome wide