Epithelial alarmins: a new target to treat chronic respiratory diseases.
Denislava NedevaKrzysztof KowalMihaicuta StefanGuillermo Guidos FogelbachPaschalis SteiropoulosHerberto Jose Chong-NetoAngelica TiotiuPublished in: Expert review of respiratory medicine (2023)
Despite progress in the understanding of the alarmins' role in the pathogenesis of CRD, all their mechanisms of action are not yet identified. Blocking IL-33 and TSLP pathways offer an interesting option to treat severe asthma and COPD but future investigations are needed to established their place in the treatment strategies.