The natural alkaloid Jerantinine B has activity in acute myeloid leukemia cells through a mechanism involving c-Jun.

Hayaa Moeed AlhuthaliTracey D BradshawKuan-Hon LimToh-Seok KamClaire H Seedhouse

Published in: BMC cancer (2020)

This work provides the first evidence of cytotoxicity of JB against AML cells and identifies ROS-induced c-Jun activation as the major mechanism of action.

Keyphrases

induced apoptosis
cell cycle arrest
acute myeloid leukemia
oxidative stress
high glucose
dna methylation
reactive oxygen species
acute lymphoblastic leukemia