Comparative Gene Expression Profiling of Primary and Metastatic Renal Cell Carcinoma Stem Cell-Like Cancer Cells.

Mohammed Imran KhanAnna M CzarneckaSławomir LewickiIgor HelbrechtKlaudia BrodaczewskaIrena KochRobert ZdanowskiMagdalena KrólCezary Szczylik

Published in: PloS one (2016)

All together, RCC-CD105+ cells present stemlike properties. These stem cell-like cancer cells may represent a novel target for therapy. A unique gene-expression profile of CD105+ cells could be used as initial data for subsequent functional studies and drug design.

Keyphrases

stem cells
induced apoptosis
gene expression
cell cycle arrest
metastatic renal cell carcinoma
dna methylation
endoplasmic reticulum stress
genome wide
signaling pathway
single cell
electronic health record
cell death
copy number
transcription factor
nk cells
pi k akt