DC-SIGN receptor is expressed by cells from cutaneous leishmaniasis lesions and differentially binds to Leishmania (Viannia) braziliensis and L. (Leishmania) amazonensis promastigotes.
Carolina de O Mendes-AguiarMilene Yoko Kitahara-OliveiraAna Cristina Oliveira de AlmeidaMarcia Pereira-OliveiraManoel Paes de Oliveira NetoClaude PirmezElizabeth Pereira SampaioAdriano Gomes-SilvaAlda Maria Da-CruzPublished in: Memorias do Instituto Oswaldo Cruz (2023)
Our results demonstrate that DC-SIGN receptor is present in L. braziliensis CL lesions and interact with Lb promastigotes. Moreover, the differences in the binding pattern to Lb and La suggest DC-SIGN can influence in a difference way the intake of the parasites at the first hours after Leishmania infection. These results raise the hypothesis that DC-SIGN receptor could participate in the immunopathogenesis of American tegumentary leishmaniasis accounting for the differences in the outcome of the Leishmania spp. infection.