Characterization of Antigen Escape Mutations in Chronic HBV-Infected Patients in Upper Egypt.

Mohamed Ahmed El-Mokhtar Helal F Hetta Mohamed A Mekky Doaa M Abd El-KareemMohammed RamadanMohammed SalahNahed A MohamedEman A El-MasrySara AdelIbrahim M Sayed

Published in: Infection and drug resistance (2021)

We described for the first time the prevalence and characterization of vaccine escape mutants in CHB patients in Upper Egypt. Mutational analysis of the "a" determinant region revealed the presence of a wide spectrum of mutants in the circulating HBV isolates that could be a potential threat to HBV diagnosis, therapy success, and HBV vaccination program in Upper Egypt.

Keyphrases

hepatitis b virus
liver failure
end stage renal disease
newly diagnosed
chronic kidney disease
prognostic factors
stem cells
quality improvement
single cell
patient reported outcomes
climate change
genetic diversity
wild type
replacement therapy